Stem Cells Protect Against Defective Copies

first_imgThe Pasteur Institute (see Louis Pasteur) has found evidence supporting a controversial theory known as the “immortal DNA” theory.  According to News-Medical.Net, researchers at the institute believe that stem cells keep the best copies and allow only defective ones to differentiate and specialize.  If so, this may be another mechanism for minimizing the effects of mutations.  The lead scientist said,this is an exciting finding, as it seems to defy one of the basic rules of cell biology and genetics: that genetic material is distributed randomly.  It appears that the cellular machinery distinguishes old from new when it comes to DNA, and it may use this distinction to protect the body from mutations and cancer.  It is also possible that this mechanism is used to silence gene expression in the stem cell.According to the press release, the research was published in Nature Cell Biology.Oh no, this is bad news for us Darwinians.  We need those mutations to advance the tree of life.  If the ID people get hold of this, it will give them another hammer to beat us with.  Let’s pre-empt it with a good just-so story.  Can somebody come up with one?  Anyone?(Visited 5 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

SA paddlers take on world’s longest canoe race

first_img “Sleep deprivation was the biggest one,” he said of the challenges he faced in 2007. “Obviously you have to be very fit. You start hallucinating, there is tendonitis in your wrists, sore bums from sitting down the whole time. “The river is quite dangerous,” he added. “You can’t go too close to the bank. Branches and massive trees fall out, so they are 30 metres into the river and you can’t see the branches and the river is flowing really fast, and you get hooked up in those. The water temperature is four or five degrees.”A bigger boat Due to the nature of the race, it is entirely possible that, apart from the start, they might not see any of their fellow competitors at all along the route. The vast distance and the tough requirements of the test that lies in weight means the Dung Beetles have to use a bigger boat than usual. “It’s a sea kayak,” Paul explained , “bigger than our kayaks because you’ve got a long list of mandatory things you have to take, like tents, sleeping bags, two stoves, three weeks of food, bear spray, flares. It has two hatches, so you are taking a lot of kit. “The boat will weight from 80 to 100 kilograms by the time we are packed up and ready to start. It’s an expedition.”Spot devices The duo will also carry two Spot devices with them, in case one of the tracking gadgets breaks down. The devices allow them to be tracked by satellite. Every day, they must stop paddling by 23:00, when it gets dark, and within 15 minutes they must press their device. The competitors are allowed to start paddling the next morning at 05:00, when it becomes light again. They must press the Spot device every six hours. In case of an emergency, the Spot devices contain a rescue mechanism, which would alert the Coast Guard on the United States side of the border and the Royal Canadian Mounted Police in Canada.Goal Paul and Boshoff have spent six months preparing for the Yukon 1 000, putting in training sessions of up to 100 kilometres a day. They’re planning to finish the distance in eight days, although seven days would be something they would be very pleased with, said Paul. The race record is six-and-a-half days. Keeping up their energy will be vital to achieving their goals and finishing the race, he added. Food “We both trained by going to a dietician. Our intake is all based on calories and what you are burning up every day, so we have balanced that out,” Paul said. “You can’t replace the calories as fast as you are burning them. We eat every half- hour, or at least every hour. A lot of that comes from energy drinks, probably 75 percent. You have to drink about half-a-litre every hour. You have to drink at least eight litres every day. That’s what we plan to do.” Paul’s and Boshoff’s progress can be tracked on their blog – The South African Dung Beetles Blog 17 July 2014 Only 12 teams have been brave enough to enter this year’s edition of the longest canoe race in the world, the Yukon 1 000 – meaning 1 000 miles (1 600 kilometres) – and they include the “South African Dung Beetles”, Duncan Paul and Donovan Boshoff of the Natal Canoe Club. The event starts in Whitehorse, the capital of the Yukon, in Alaska, and concludes at the Alaska Pipeline/Dalton Highway after seven to 12 days of paddling for 18 hours a day. Clearly, it is not for the faint of heart.Unsupported As an unsupported race, the contestants have to look out for their own wellbeing and that means carrying three weeks of food supplies. “You have to take three weeks of food with you because if you have bad weather conditions or someone gets injured there is no way you can be helped out there,” Paul said at a send-off function in Pietermaritzburg on Tuesday. On Wednesday, he and Boshoff jetted off on their way to Canada for the start of the Yukon 1 000, which takes place from Monday, 21 July. Paul previously took part in the Yukon River Quest in 2007, completing the mammoth 740 kilometre journey with fellow Natal Canoe Club member Colin Burden in 50 hours, while taking only one seven-hour and one three-hour break along the way.Useful knowledge Thanks to that previous experience, Paul explained, he learned some useful things, like the kinds of trials he and Boshoff can expect to face in the even longer Yukon 1 000. last_img read more

Now That We’ve Won Your Business, I’d Like To Learn A Little About You

first_imgI heard a salesperson say something fascinating (and disturbing) today. He said, “And it’s really important for us to learn about our clients needs when we have our new client kick off meeting.What? When we have the kick off meeting?You’re probably wondering how the salesperson wins new business. He wins new business through an RFP process executed and operated by brokers. He is universally behind the sales process. In this process, everything the buyer wants is detailed in a request for proposal. The sales organization generally has to agree to everything in the request proposal as a condition of being allowed to compete (or, more accurately, provide pricing). But if all the needs are captured in a request for proposal why wouldn’t those needs be known before a kick off meeting? And the answer is simple: the kick off meeting is where the buyer and seller interact for real for the first time; it’s where the discover their real needs.In FrontSelling from behind the process is terrible. It’s terrible for sales organizations. And it’s terrible for organizations that are buying. Without truly understanding the client’s needs, the sales organization is set up to fail. They haven’t done the work that would allow them to succeed, and they’re still behind even after having won. In fact, they may not have been the right choice to begin with. They may just have been the best show horse the boardroom.This salesperson’s organization churns clients. They lose accounts through the deep dissatisfaction that usually starts about six months into their contract. The reason they have a systemic problem with churn is because they’ve adopted a process that doesn’t allow them to know their customer and their real need, and that same process doesn’t allow the customer to know there suppliers real solution or capabilities.If you’re just learning about your clients needs at kick off, you’re both way behind. In human relationships and complex business dealings, slow is fast and fast and slow.QuestionsHow much time do you spend really understanding your dream client’s needs?Mistakes are made, but whose fault is it if you are surprised at your dream client’s difficult demands after having won?How do you get in front of the sales process when your buyer’s process is at arm’s length?last_img read more

Jan Goldsmith on what to expect next with Justice Kavanaugh swearing in

first_img Posted: October 8, 2018 00:00 00:00 spaceplay / pause qunload | stop ffullscreenshift + ←→slower / faster ↑↓volume mmute ←→seek  . seek to previous 12… 6 seek to 10%, 20% … 60% XColor SettingsAaAaAaAaTextBackgroundOpacity SettingsTextOpaqueSemi-TransparentBackgroundSemi-TransparentOpaqueTransparentFont SettingsSize||TypeSerif MonospaceSerifSans Serif MonospaceSans SerifCasualCursiveSmallCapsResetSave SettingsSAN DIEGO (KUSI) – Justice Kavanaugh is replacing Justice Anthony Kennedy, who was the court’s swing vote on critical issues including same-sex marriage, abortion, and campaign finance.KUSI contributor Jan Goldsmith, who served as a Superior Court Judge for 10 years, joined us in studio on what to expect with Justice Kavanaugh swearing in. Jan Goldsmith on what to expect next with Justice Kavanaugh swearing in October 8, 2018 KUSI Newsroom, KUSI Newsroom Categories: Local San Diego News, National & International News, Politics Tags: Brett Kavanaugh FacebookTwitterlast_img read more

SELECTMEN NEWS Selectmen To Discuss Senior Center Palmer Park WHS Gym Floor

first_imgWILMINGTON, MA — The Wilmington Board of Selectmen meets this Monday, September 9, 2019 at Town Hall (Room 9) at 7pm. An Executive Session precedes the meeting at 6:15pm.There are some noteworthy items on the agenda, including:Selectmen will consider the request of Rick Lowe, of Tremezzo Pizzeria, to obtain a Common Victualer License for 296 Shawsheen Avenue.Public Buildings Superintendent George Hooper will provide an update the recent lighting project at Palmer Park.Elderly Services Director Terri Marciello will provide an update on her department’s programs and offerings.Town Manager Jeff Hull will provide an update on the high school gym floor replacement project.Town Manager Jeff Hull will share a letter from the Attorney General’s Office approving Articles 39-42 from this year’s Annual Town Meeting.Town Manager Jeff Hull will share a letter sent to the Executive Office of Elder Affairs regarding Senior Center funding.Selectmen will be invited to an upcoming Flagpole Dedication Ceremony at Silver Lake.Selectmen will consider ratifying the Town Manager’s appointments of Arianna Faro to the Commission on Disabilities and Christine Johnston to the Historical Commission.Selectmen will consider the request of the Recreation Department to conduct its 52nd Annual Horribles Parade on Sunday, October 27, 2019.Selectmen will consider the request of Wilmington Methodist Church (c/o John Arvanitis) and Boy Scouts Troop 56 (c/o John Mainini) to sell Christmas trees.Selectmen will consider the request of the Wilmington Sons of Italy and Wilmington Band Parents to reschedule their Flea Market from September 7 to October 19 in the Town Common Parking Lot.Selectmen will consider the request of Gigi Shenloogian to light the Town Common purple during the month of October for Breast Cancer Awareness Month.The meeting will be telecast live by Wilmington Community Television on WCTV — Channel 9 on Comcast and Channel 37 on Verizon.  The meeting will also be streamed on WCTV’s website HERE.Wilmington Apple intends to report on many of the items above – and any other news that comes from the meeting — over the next two weeks. Wilmington Apple will live-tweet the meeting HERE.Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email wilmingtonapple@gmail.com.Share this:TwitterFacebookLike this:Like Loading… RelatedSELECTMEN NEWS: Selectmen To Discuss Need For Fire Substation At Wednesday, August 7 MeetingIn “Government”SELECTMEN NEWS: Public Buildings Dept. Outlines Projects This Summer, Including School ImprovementsIn “Government”SELECTMEN NOTEBOOK: 6 Things That Happened At This Month’s Selectmen’s MeetingIn “Government”last_img read more

Mass funeral held for Myanmar plane crash victims

first_imgHeartbroken relatives gathered Friday for the funeral rites of the first victims of a military plane crash off Myanmar’s southern coast, as search teams battled heavy rains and churning waves to find scores more people presumed lost at sea.Most of the 31 dead retrieved from the Andaman Sea so far have been women and children after a fraught search by navy ships, planes and helicopters hampered by sweeping rains.A total of 122 people were on board the Chinese-made Shaanxi Y8 military aircraft when it crashed on Wednesday during a routine flight from the southern city of Myeik to Myanmar’s commercial hub of Yangon.Hundreds gathered in a cemetery outside Dawei town on Friday afternoon to bid goodbye to loved ones whose bodies had been pulled from the water the previous day on San Hlan beach, a two hour drive away.Chanting from Buddhist monks filled a hall used for the ceremonies as 10 flimsy wooden coffins were laid out.One woman fainted and had to be carried out and many others broke down wailing as the service went on.Mourners then moved outside and watched as black smoke from the cremated coffins poured out of nearby towers, drifting across the sky.“My husband identified my nephew’s body. I’m so sorry,” said a tearful Khine Zar Win, who lost her youngest brother, his wife and two-year-old nephew in the plane crash.Another mourner, Aye Aye, said five members of her friend’s family were killed in the crash.“I couldn’t sleep when I heard about them,” she said. “We lived together like a family for 15 years in the military before my husband retired.”“I have no words,” added one woman, whose daughter and grandson were on the plane. “We are so sad.”More than half of the passengers on the aircraft were from military families, including 15 children, according to the army. The rest were soldiers and flight crew.The military said on Friday it had identified 16 of the dead so far.There has been no official explanation for the cause of the crash, one of several deadly incidents involving Myanmar military aircraft in recent years.Monsoon season brings heavy rains and strong winds every year, but there were no reports of major storms along the plane’s flight route when it went missing.Storms hamper search -Fishing boats helped navy vessels and military aircraft as they continued to hunt for the wreckage on Friday, despite tides reaching over 2.5 metres, the military said in a statement.But by the afternoon officials had not announced the retrieval of any more bodies.“We are having difficulty because of the strong winds and tide,” Major Aung Win, police chief of Launglon township, told AFP.The military said the aircraft was flying above 18,000 feet (5,486 metres) when it lost contact with air traffic control at 1:35 pm (07:05 GMT) on Wednesday.The military has described the captain as a “seasoned” pilot with more than 3,000 hours flying experience.Gerry Soejatman, an independent aviation expert based in Jakarta, said initial information indicated something went wrong “not long after or just before reaching cruising altitude”.Myanmar’s former junta bought several Y8s-four-engine turboprop jets used for medium range flights-during their 50 years of isolated rule, when they were squeezed by Western sanctions.The plane’s maker, China National Aero-Technology Import & Export Corporation, has pledged to assist with investigations into the crash.Several pieces of debris that appeared to be from the wreckage, including tyres, life jackets and some luggage, have also been salvaged.last_img read more

Grand Opening of Word of Faith Church

first_imgWord of Faith will be celebrating their grand opening April 21-24. The church is located at the Atrium, 4 W University Pkwy, Baltimore, MD 21218 in back of the Doubletree Hotel. Contact the church office at 410-662-5587 for more information.last_img

Ecologists suggest it is time to rethink the modern lawn

first_img More information: Maria Ignatieva et al. An alternative urban green carpet, Science (2018). DOI: 10.1126/science.aau6974 Credit: CC0 Public Domain A pair of urban ecologists, one from Australia, the other Sweden, suggests in a Perspective piece published in the journal Science that it might be time to rethink the idea of the modern lawn. In their paper, Maria Ignatieva and Marcus Hedblom note that the natural benefits of green lawns are far outweighed by negative environmental consequences, and because of that, new forms of groundcover need to be explored. Explore further © 2018 Phys.org Journal information: Sciencecenter_img The expanse of cut green grass that surrounds many houses and serves as a draw to parks and other outdoor places is not as green as it might look. The modern lawn requires not only a lot of water, but fertilizer. It also requires mowing, in most cases using gas-powered machines that spew carbon monoxide and other toxins into the air. Ignatieva and Hedblom note that it is true that lawns offer some positive benefits such as pulling carbon dioxide out of the air, but the negative aspects of lawn care far outweigh their benefits. They note that globally, lawns currently occupy land space equivalent to England and Spain combined. Lawns also currently require an enormous amount of water—in arid regions, lawns account for 75 percent of water consumption. They also note that weed killers and fertilizers wind up in the water table. And artificial turf, they note, is not a likely solution. It doesn’t contribute to carbon sequestering, causes problems with water runoff, and might be poisoning local water tables.Because of the obvious drawbacks, the researchers suggest that it is time for the world to rethink the idea of a lawn. They note that some communities have already begun to do so by allowing natural meadows in place of lawns. Such meadows, they note, can be made aesthetically pleasing by using grasses suited for the purpose. They also note that in some places, such as sections of Berlin, landscape has been allowed to grow wild. More realistically, they suggest research into plant types might result in the development of naturally short grasses that do not need much water to survive. In the end, they suggest that perhaps a combination of efforts might work. But for that to happen, people need to start reframing the mindset of modern groundcover. Citation: Ecologists suggest it is time to rethink the modern lawn (2018, October 12) retrieved 18 August 2019 from https://phys.org/news/2018-10-ecologists-rethink-modern-lawn.html Grow, mow, mulch: Finding lawn’s value This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more