DENVER — Three-fourths of Americans say it’s inevitable that marijuana will be legal for recreational use across the nation, whether they support such policies or not, according to a public opinion poll released Wednesday that highlights shifting in attitudes following an era of drug war and “tough on crime” legislation.The Pew Research Center survey also shows increased support for ending mandatory minimum prison sentences for non-violent drug offenders and doing away altogether with jail time for small amounts of marijuana. The opinions come as public debate on these topics has led lawmakers around the nation to consider policy changes. Since California became the first state to legalize medical marijuana in 1996, at least 19 others, and the District of Columbia, have followed suit, including two that have approved recreational use. More than a dozen state legislatures considered legalization measures this year. Meanwhile, critics and political leaders, both liberal and conservative, have clamored for an end to harsh drug sentences, saying mandatory minimums have contributed to prison overcrowding, civil rights violations and strained budgets. U.S. Attorney General Eric Holder has been pushing Congress to overhaul drug sentencing policies. The telephone survey found that 75 percent of respondents — including majorities of both supporters and opponents of legal marijuana– think that the sale and use of pot eventually will be legal nationwide.
India and Myanmar army hold first ever joint drill from Monday. Photo: Defence Ministry of IndiaThe first ever joint military drill of India and Myanmar started at the Joint Training Node in Umroi of Meghalaya on Monday.Fifteen officers from the Myanmar army and 16 from the Indian army are taking part in the five-day drill.India’s defence spokesperson lieutenant colonel Suneet Newton told newsmen that the aim of this joint exercise was to exchange expertise and tactics of the armed forces as well as strengthening the friendship between the two forces.Tactics and use of superior technology to fight militancy will be emphasised in the drill, which will help army officials of both the countries, the spokesperson claimed.The joint exercise has reportedly been organised to train the Myanmar army officials for participation in the United Nations Peacekeeping Operations under the UN flag.Indian army organised the joint drill with its Myanmarese counterpart at a time when the latter drew huge global flak for persecuting country’s Rohingya Muslim minority.About 700,000 Rohingyas fled the persecution in the northern Rakhine state, which the United Nations calls a “textbook example of ethnic cleansing”, since 25 August this year and took refuge in Bangladesh.
Bangladesh Awami League president and prime minister Sheikh Hasina exchanges views with leaders of the All European Awami League (AEAL) at Hotel Claridges in London on 22 April. Photo: PIDBangladesh Awami League president and prime minister Sheikh Hasina Sunday directed the All European Awami League (AEAL) leaders to give a befitting reply to what she said BNP-Jamaat propaganda against the country and government abroad, reports BSS.”The BNP-Jamaat nexus, who amassed huge amount of money through illegal ways, is now carrying out false propaganda against the country and the government abroad through various means. So, you’ll have to give a befitting reply to it,” she said when a delegation of the AEAL leaders called on her at her hotel suite here this morning in London, UK.The Bangladesh Nationalist Party (BNP) is the main opposition political party led by Hasina’s arch enemy Khaleda Zia who landed in jail in last February and Bangladesh Jamaat-e-Islami is a longstanding ally of BNP.AEAL president Anil Das Gupta and general secretary MA Gani led the delegation.PM’s press secretary Ihsanul Karim briefed reporters after the meeting.He said the European Awami League leaders apprised the prime minister of different aspects of the organisation.The press secretary said the prime minister also gave directives to the leaders to further strengthen the organisation and maintain unity among them.Sheikh Hasina recalled about how the AL was formed in Europe amid adverse situation after the brutal assassination of Bangabandhu in 1975.In this connection, she asked the present leadership of the European Awami League to properly evaluate those veteran leaders, who played a crucial role in organising Awami League in Europe at that time.”The Awami League will have to move ahead through combined coordination of its young and veteran leaders,” she commented.Hasina claimed that she personally tolerated much pain and sacrificed a lot only for the cause of the country’s development.
Prime minister Sheikh HasinaPrime minister Sheikh Hasina returned home from Sydney in the early hours of Monday wrapping up her three-day official visit to Australia to join the Global Summit of Women.In the summit, the prime minister was conferred on the prestigious Global Women’s Leadership Award-2018.A Thai Airways flight carrying the prime minister and her entourage members landed at Hazrat Shahjalal International Airport in Dhaka at 12:50am.On her way home from Sydney, the prime minister made a nearly one hour stopover in the Thai capital of Bangkok.Earlier, the prime minister departed Kingsford Smith International Airport in Sydney for Dhaka at 4:00pm local time (12 noon BST).Bangladesh high commissioner to Australia Md Sufiur Rahman saw the prime minister off at the airport.In Sydney, the prime minister received the Global Women’s Leadership Award-2018 on Friday at a gala dinner at International Convention Centre (ICC).The US-based Global Summit of Women conferred the award on Sheikh Hasina for her leadership in women’s education and entrepreneurship in Bangladesh.The prime minister held a meeting with Australian counterpart Malcom Turnbull at his residence on Saturday, while Vietnamese vice president Dang Thi Ngoc Thinh and Australian foreign minister Julie Bishop called on her in the Intercontinental Sydney Hotel.Sheikh Hasina visited Western Sydney University and joined a community event at Sofitel Hotel in Sydney on Saturday.
Former president of Bangladesh and Jatiya Party chairman Hussain Mohammad Ershad. Prothom Alo File PhotoThe body of former president of Bangladesh and Jatiya Party chairman Hussain Mohammad Ershad will be taken to Rangpur on Tuesday, say party officials.The 89-year-old leader of the opposition in the Jatiya Sangsad (national parliament) died at the Combined Military Hospital in Dhaka this (Sunday) morning.JP presidium member Khaled Akhter confirmed this to Prothom Alo.The Inter Services Public Relations Directorate (ISPR) assistant director Rashedul Alam Khan also said that the former president died around 7:45am.Ershad’s wife Raushan Ershad and son Saad Ershad went to CMH around 8:00 in the morning, JP said.The body has been kept at CMH morgue.JP chairman’s deputy press secretary Khandaker Delwar Jalali told Prothom Alo in the morning that the first namaaz-e-janaza of Ershad will be held central army mosque after the Zuhr prayers.His second janaza will be held at the South Plaza of the Jatiya Sangsad at 10:00am tomorrow, Monday, while the third janaza will be held at Baitul Mukarram, the national mosque of Bangladesh, at 11:00am on the same day.Ershad’s body will be taken to Rangpur on Tuesday by a helicopter and a janaza will be held there. His body will then be brought back to Dhaka.He will be buried at the army graveyard in Dhaka as was his wish, said Jatiya Party presidium member Ziauddin Bablu.JP acting chairman GM Quader on Saturday said his brother HM Ershad had been on life support at the CMH.Physicians had long been trying to make his kidney and liver functions normal, but there was no improvement in this regard, he added.Ershad, also the leader of the opposition in parliament, was admitted to the CMH on 27 June as his condition deteriorated.Ershad was born in Cooch Behar of the then British India on 1 February 1930. His father Mokbul Hossain served as a minister of the-then Maharaja of Cooch Behar. Later, his family shifted to Rangur.
Share Former President George H.W. Bush is complimenting the medical workers helping him recover from an infection at Houston Methodist Hospital. But he said that once doctors give him the OK to leave, “I’m outta here.”Quite moved by this announcement by @MethodistHosp. The atrium is beautiful, but recent developments notwithstanding I have not taken up residence here. The doctors, nurses and support staff are so nice, but the second I get the green light I’m outta here. https://t.co/VkWHmxzI6c— George Bush (@GeorgeHWBush) May 3, 2018The 93-year-old Bush was admitted to the Methodist on April 22, the day after attending the funeral for his wife, Barbara. The pair were married for 73 years.Bush tweeted on Thursday that everyone at the hospital has been “so nice,” and that he was especially moved when a three-story atrium at the hospital was named to honor him and his late wife.But he jokes that he doesn’t want people to think he’s “taken up residence” at the hospital.Family spokesman Jim McGrath has said the nation’s 41st president has been regaining his strength.
Job seekers in the Baltimore-Washington region with a criminal history could find one obstacle to employment –a prison record—swept aside by legislation, commonly known as ‘Ban the Box’ legislation, that prevents would-be employers from inquiring about their past. Baltimore Mayor Stephanie Rawlings-Blake May 28 signed a bill passed by the Baltimore City Council at the end of April that prohibits some employers from questioning job applicants about their criminal background. It had been argued that such questions often throw cold water on otherwise bright job prospects. “This bill is about tearing down those barriers, breaking the barriers to employment,” said Mayor Rawlings-Blake as she signed the legislation that the Baltimore City Council had been debating for weeks. “This is about making sure that we put Baltimore back to work,” she said. “At the end of the day, we have to figure out innovative ways of growing our city,” said Councilman Nicholas Mosby, sponsor of the bill. Legislation similar to that signed into law in Baltimore, is advancing through the D.C. Council. D.C. Council member Tommy Wells’ (D-Ward 6) attempt to reduce the unemployment rate in D.C. by making the hiring process less biased to ex-offenders was unanimously approved by the Committee on the Judiciary and Public Safety May 28. The D.C. ‘Ban the Box’ legislation, entitled the Fair Criminal Record Screening Act of 2014, would remove questions about an applicant’s criminal history from private employer’s job applications, prohibit any inquiry into an applicant’s arrest record and delay inquiry into an applicant’s criminal convictions until after the first interview.“Gaining employment is one of the biggest barriers facing returning citizens,” Wells said in a press release May 29. The legislation is expected to be included on the D.C. Council’s June 3 meeting agenda, Kouri C. Marshall, senior advisor and director of external affairs for Wells’ office told the AFRO in an email. The council will have to vote on the bill twice. According to a 2012 report from the National Institute of Justice, African Americans account for 28 percent of all arrests even though they make up less than 14 percent of the U.S. population. The report said penalties are more likely to be enforced on ex-offenders with African American or Latino backgrounds as opposed to their White counterparts. “This bill is a crucial step in addressing that challenge. The passage of ‘Ban the Box’ represents another important victory for social justice in the District of Columbia,” Wells said. In addition to Baltimore, thirteen other jurisdictions have adopted “Ban the Box” legislation including Rochester and Buffalo, N.Y., according to Mondaq, a news and regulatory information web site.
By ASHRAF KHALIL, Associated PressWASHINGTON (AP) — When Washington’s $500 million Museum of the Bible held its grand opening in November 2017, attended by Vice President Mike Pence, there were questions even then about the authenticity of its centerpiece collection of Dead Sea Scrolls.Now the museum has been forced to admit a painful truth: Technical analysis by a team of German scholars has revealed that at least five of the museum’s 16 scroll fragments are apparent forgeries.In this Oct. 30, 2017, file photo, security workers stand inside a large open stairwell area at the Museum of the Bible in Washington. Less than a year after it opened, Washington’s Museum of the Bible is admitting that at least part of its centerpiece collection of Dead Sea Scrolls are fakes. The embarrassing announcement on Oct. 22, 2018, is the culmination of a technical analysis by a team of German scholars. (AP Photo/Jacquelyn Martin, File)The announcement has serious implications not only for the Bible Museum but for other evangelical Christian individuals and institutions who paid top dollar for what now seems to be a massive case of archaeological fraud.Jeffrey Kloha, chief curator for the Museum of the Bible, said in a statement that the revelation is “an opportunity to educate the public on the importance of verifying the authenticity of rare biblical artifacts, the elaborate testing process undertaken and our commitment to transparency.”The scrolls are a collection of ancient Jewish religious texts first discovered in the mid-1940s in caves on the western shore of the Dead Sea in what is now Israel. The massive cache of Hebrew documents is believed to date back to the days of Jesus. With more than 9,000 documents and 50,000 fragments, the entire collection took decades to fully excavate.Most of the scrolls and fragments are tightly controlled by the Israeli Antiquities Authority. But around 2002, a wave of new fragments began mysteriously appearing on the market, despite skepticism from Biblical scholars.These fragments, they warned, were specifically designed to target American evangelical Christians, who prize the scrolls. That appears to be exactly what happened; a Baptist seminary in Texas and an evangelical college in California reportedly paid millions to purchase alleged pieces of the scrolls.Also eagerly buying up fragments was the Green family — evangelical Oklahoma billionaires who run the Hobby Lobby chain of craft stores and who famously sued the Obama administration on religious grounds, saying they didn’t want to pay to provide their employees access to the morning-after pill or intrauterine devices.The Greens are the primary backers of the Museum of the Bible and went on an archaeological acquisition spree in the years leading up to the museum’s opening. In addition to the alleged Dead Sea Scrolls fragments, the Greens ran afoul of the Justice Department, which said they had acquired thousands of smuggled artifacts looted from Iraq and elsewhere. The family agreed last year to return those artifacts and pay a $3 million fine.
Kolkata: West Bengal Congress president Somen Mitra Monday said BJP president Dilip Ghosh’s comment that Mamata Banerjee has the best chance to become PM, is proof of “tacit understanding” between TMC and the BJP. “Dilip Ghosh’s statement that Mamata Banerjee has the best chance to become the first Bengali Prime Minister is not an isolated statement. It is a reflection of tacit understanding between both the parties in the state. We have been saying this for a long time but now the cat is out of the bag,” Mitra told reporters here. Also Read – Rain batters Kolkata, cripples normal life Ghosh had, however, on Sunday made a U-turn and said his remark the day earlier on Chief Minister Mamata Banerjee’s prime ministerial prospects was made in jest. Mitra termed Ghosh’s u-turn as a “lame excuse” and said that the people of the state very well understood the kind of “political setting” that exist between parties. Mitra claimed that by making the statement, Ghosh has virtually accepted that the BJP will not return to power in the 2019 Lok Sabha polls and might extend support to Mamata Banerjee in such a scenario. Also Read – Speeding Jaguar crashes into Mercedes car in Kolkata, 2 pedestrians killed Commenting on the general strike called by various Left trade unions on January 8 and 9, Mitra said TMC’s opposition to the strike call is another example of ‘TMC-BJP fixed match’ in the state. “Why is she opposed to the strike call in the state? It is not against the state government. It is a nationwide strike call against the policies of the Modi government. This only proves that the TMC and BJP are both on the same page regarding economic policies and TMC’s call to fight against BJP is nothing but a farce,” he said. As many as 10 central trade unions have called a nationwide general strike on January 8 and 9, against the “anti-people” policies of the Centre and have placed a charter of 12 demands before the Centre. The demands include minimum wage, universal social security, workers’ status and including pay and facilities for the scheme workers, against privatisation of public and government organisations. Leaders and activists of various parties including TMC, Union Muslim League and CPI(M) Monday joined Congress and vowed to fight against the communal politics of TMC and BJP in the state.
Yesterday, PyPy 7.0 was announced in a blog post. It is a triple release for different Python versions. PyPy is a compliant Python interpreter which can be considered a replacement for CPython 2.7, 3.5, and 3.6. It’s faster due to the integrated tracing JIT compiler. The release supports x86 machines with common OSes, PPC64, and s390x running Linux. Since the ARM buildbots are out of service currently, binaries for ARM architecture will not be released. PyPy 7.0 includes the following interpreters. PyPy2.7 is an interpreter with support for syntax and features of Python 2.7 which will lose official support next year. PyPy3.5, supports the stable Python 3.5 PyPy3.6-alpha which is the first official PyPy release supporting 3.6 features. All of the three interpreters share a similar codebase allowing this triple release. Until packages can be distributed downstream, wheel (whl) packages are available for some common packages. GC hooks has been improved. It’s now possible to manage the GC by using a combination of gc.disable and gc.collect_step manually. The cffi module included in PyPy has been updated to version 1.12. The cppyy backend is also updated to version 1.4. For a JIT friendly experience, use the new versions to wrap your C and C++ code. PyPy 7.0 is fully compatible with the previous version. Several issues and bugs raised by the PyPy community have been addressed. PyPy3 and Windows PyPy3.5 releases are not yet up to quality to be used in production. There are open issues and the compatibility is not complete. The utf8 branch to change the internal representation of unicode to utf8 will be added in one of the future releases. Read next Python Software foundation and JetBrains’ Python Developers Survey 2018 Python steering council election results are out for January 2019 Introducing RustPython, a Python 3 interpreter written in Rust
Disabled people’s organisations (DPOs) have accused ministers of attacking freedom of expression and trying to muzzle their critics, after announcing new rules that will ban charities from using government grants to lobby politicians and civil servants.DPOs say that the new rules, announced by the Cabinet Office, will make it even harder to campaign to promote the rights of disabled people.The new rules say that all government grant agreements from 1 May will forbid charities from spending money on work that is intended to influence “parliament, government or political parties”, or “legislative or regulatory action”.But there has been Cabinet Office confusion over whether the new rules would apply to charities responding to government consultations, or trying to improve proposed legislation as it passes through parliament.And the Cabinet Office risked ridicule after it told Disability News Service that government departments would be holding their own consultations on the new rules in the lead-up to their introduction on 1 May.This holds out the prospect of charities being asked to comment on a policy that could prevent them taking part in such consultations in the future.Asked whether this suggested “double standards”, a Cabinet Office spokeswoman said: “I don’t really see a problem at all.”Henrietta Doyle, policy office for Inclusion London, said the new rules showed that the government “dislikes criticism” and was “trying to clamp down on the voluntary sector highlighting the damage their policies are causing”. She said: “For [Cabinet Office minister] Matthew Hancock to call it ‘the farce of government lobbying government’ shows little understanding that charities provide government with an independent opinion about the impact of their policies on the population.“The proposal inhibits the democratic process. Government policy should be examined by the third sector, which includes disabled people and their organisations.“If a policy is damaging disabled people’s lives then government should be informed of this and voluntary organisations play a vital role in providing this feedback to government and it should not be inhibited in any way, regardless of where the funding comes from.”Tara Flood, director of The Alliance for Inclusive Education (ALLFIE), said the new clause was “appalling”.She said it was already becoming more difficult for campaigning organisations like ALLFIE to secure meetings with government decision-makers, and to find the time and resources to respond to the frequent consultations sent out by government departments, such as the Department for Education.She said: “There is a real resistance, particularly among politicians, to meet with those of us who are going to challenge what politicians say.”Flood said the new clause would also intensify the competition for grants from the few organisations that still fund campaign work, while some charities may just decide to stop campaigning completely.Disability Rights UK said the new clause “fundamentally undermines the value of the third sector in bringing insight and feedback from the people we represent”. Sue Bott, deputy chief executive of Disability Rights UK, said: “It goes against open policy-making and is counter to the ideas of co-production where those affected by a policy have the opportunity to help shape it. “We think this attack on the freedom of expression undermines good policy-making and in the end, far from being good for taxpayers as it is claimed, will do the exact opposite, as poor policy will result.”She said the new clause also contradicts the Compact, the agreement between the government and voluntary organisations across England to ensure that they “work effectively in partnership”. Clause 1.1 of the Compact states that the government will “respect and uphold the independence of civil society organisations to deliver their mission, including their right to campaign, regardless of any relationship, financial or otherwise, which may exist”.Picture: Social care minister Alistair Burt speaking at a meeting organised by the charity-funded Care and Support Alliance at the 2015 Tory party conference
News reporter February 24, 2017 Tom Brant Add to Queue 2 min read –shares Image credit: via PC Mag Fireside Chat | July 25: Three Surprising Ways to Build Your Brand This story originally appeared on PCMag Next Article Learn from renowned serial entrepreneur David Meltzer how to find your frequency in order to stand out from your competitors and build a brand that is authentic, lasting and impactful. Waymo, which took over Google’s self-driving car project, says its trade secrets are now in Uber’s hands. Uber Stole Trade Secrets, Alphabet Subsidiary Alleges Uber A former employee stole trade secrets from Google’s self-driving car project and brought them to a startup that was later acquired by Uber, according to a complaint filed in federal court on Thursday.Waymo, a division of Google’s parent company Alphabet that took over the search giant’s self-driving car project last year, filed a complaint against Uber’s subsidiary Otto, claiming trade secret misappropriation, patent infringement and unfair competition.The complaint alleges that Otto co-founder Anthony Levandowski downloaded more than 14,000 proprietary design files — 9.7GB worth of data — for Waymo’s Lidar system in late 2015 before he left the company to found Otto.Those designs showed up in an email that Waymo received from one of its circuit board suppliers in December, according to the complaint. The email, which apparently was referring to Uber’s own Lidar design, confirmed Waymo’s earlier suspicions that Levandowski had given Waymo’s trade secrets to Uber, which acquired Otto in August 2016.”As of August 2016, Uber had no in-house solution for LiDAR — despite 18 months with their faltering Carnegie Mellon University effort — and they acquired Otto to get it,” Waymo wrote in the complaint. “By September 2016, Uber represented to regulatory authorities in Nevada that it was no longer using an off-the-shelf, or third-party, LiDAR technology, but rather using an ‘[i]n-house custom built’ LiDAR system.”Waymo investigated the matter further, and said it discovered that additional former employees — now working at Otto and Uber — also downloaded confidential Lidar information.”Our parent company Alphabet has long worked with Uber in many areas, and we didn’t make this decision lightly,” Waymo said in a statement regarding its lawsuit. “However, given the overwhelming facts that our technology has been stolen, we have no choice but to defend our investment and development of this unique technology.”An Uber spokesperson told PCMag that “we take the allegations made against Otto and Uber employees seriously and we will review this matter carefully.” Enroll Now for $5
Reviewed by Alina Shrourou, B.Sc. (Editor)Jan 29 2019The PREVENTOMICS European project will develop, from this November and for 3 years, personalized plans for nutrition and lifestyle habits to improve the health of people, based on individual traits such as physical and behavioral traits, lifestyle, genotype, preferences and physical condition. The personal health plans, which will consider consumers’ needs and requirements, will reach the recipients in the form of behavioral prompts, thanks to the use of Information and Communications Technology (ICT) tools.PREVENTOMICS (Empowering consumers to PREVENT diet-related diseases through OMICS sciences) could be applicable in the future to the personalization of any type of treatment or health condition and represents a unique service, given that “it can be validated for specific diseases or for well-defined life situations where the combination of genetic, biological, nutritional and psychological factors is relevant”, explains Josep Mª del Bas, director of the Nutrition and Health unit of Eurecat, the technology center coordinating the consortium.It is expected that PREVENTOMICS, which has 19 European partners from 7 different countries, will conclude with the introduction of six new products on the market, both in the application of new technologies to improve health (e-business) and in the form of food products intended for human consumption.To achieve this, the project will adopt a comprehensive approach in exploiting the potential of omics techniques, especially metabolomics, to know the state of metabolic health and will focus on techniques to induce a change in behaviour in people in order to deliver preventive personalized nutrition tools, accessible to everyone, that promote changes in current habits and achieve the improvement of personal health in a sustained and lasting manner.One of the innovations of the project, as explained by the scientific coordinator of the biotechnology area of Eurecat and technical coordinator of the project, Antoni Caimari, “is that it is based on a unique integration of genetic, metabolic, nutritional and psychological data”, with the application of computational modelling techniques of the metabolism, which will enable the evaluation and characterization of the most relevant physiological processes—the sustained lack of control of which can lead to the onset of different diseases, and enable the modulation of these deviations to prevent their development”.At the social level, the research carried out by PREVENTOMICS will help to sustain new healthy lifestyle habits, increase user satisfaction and confidence in a more personalized diet and promote greater adherence to the Mediterranean diet as a healthy dietary pattern in line with the recommendations of the European Food Safety Authority (EFSA).Related StoriesScientists discover rare autoimmune disease triggered by testicular cancerDiet and nutrition influence microbiome in colonic mucosaResearchers identify gene mutations linked to leukemia in children with Down’s syndromeThe project involves innovations at the research level, in interoperability and use of open source data to feed future research; at the social level, in the search for sustainable solutions with more precise information; in terms of health, by harnessing the capabilities of Information and Communications Technology to manage data from different sources; and finally, at the business level, offering more personalized services in line with the growing demand from society.To demonstrate the potential for personalization at different levels of the food value chain, PREVENTOMICS will be validated in three different scenarios using three different companies carrying out intervention studies with both healthy volunteers and volunteers with abdominal obesity who are at moderate risk of suffering from cardiovascular disease.Evolution of personalized nutrition In recent years, “the expectations around personalized nutrition have grown, but there haven’t been sufficiently precise tools nor sufficient understanding of which individual variables are affected or what the behavioral barriers are that prevent the individual from acquiring healthier habits”, explains Caimari.It is estimated that the personalized nutrition market will grow from 81 billion euros in 2015 to 110.5 billion euros in 2020, due to the increase in key trends in society, such as the growing concern for health, a better understanding of the physical condition, the ageing of the population, the increase in disposable income, changes in lifestyle and growth in emerging markets.In this regard, experts agree that the food industry should provide solutions at the individual level, in fields such as nutraceutical and health, sports nutrition, food services or mHealth.Aside from Eurecat, the following is a list of the 19 partners of PREVENTOMICS: ALDI, Alimentòmica, Onmi; Simple Feast; METEDA; Carinsa and Practio; and the research centres and universities Università di Parma, University ofa Southampton, Institute of Communication and Computer Systems, Erasmus Universiteit Rotterdam, Leitat, Wageningen University, Uniwersytet Jagiellonski in Krakow and Universiteit Maastricht, as well as the osteoarthritis patients association Osteoarthritis Foundation International (OAFI), the Spanish Consumer Organization (OCU) and the Spanish Association for Standardization (UNE). Source:https://eurecat.org/en/
Reviewed by James Ives, M.Psych. (Editor)Apr 8 2019Dr. Sunita Sah practiced general medicine for several years in the United Kingdom’s National Health Service. When she came to the United States, she noticed something strange.The U.K. guidelines for tests such as mammograms and colon cancer screenings drastically differed from those in the U.S. – even though they were based on the same medical evidence.”Having colonoscopy at the age of 50 – that struck me as rather odd when I moved to the U.S., because you don’t really hear about people having colonoscopies as a screening procedure in the U.K.,” said Sah. “It’s much less invasive to test for blood in the stool. It’s also less costly and doesn’t have the risks of undertaking a colonoscopy.”Now an assistant professor of management and organizations at Cornell, Sah and Ismail Jatoi of the University of Texas Health, San Antonio, say the treatment guidelines recommended by medical specialist organizations are more likely to call for greater use of health care services and exacerbate overdiagnosis, overtreatment and spiraling health care costs. Their commentary, “Clinical Practice Guidelines and the Overuse of Health Care Services: Need for Reform,” appeared March 18 in the Canadian Medical Association Journal.The implications are significant, she said, because guidelines are supposed to provide standard evidence-based treatment practices for all doctors.”The recommendations put out by specialty organizations – like the American College of Cardiology or the American College of Radiology – show specialty bias in recommending more aggressive and/or more frequent screening procedures,” said Sah, an expert on conflict of interest. “In the U.S. in particular, where the fee-for-service compensation model dominates medicine, which is different from countries like the U.K., you see even more recommendations for greater use of health care services.”Specialty bias refers to the tendency of physicians to recommend the treatments in which they are trained to deliver. For example, localized prostate cancer can be treated with either surgery or radiation.”If you go to a surgeon, chances are that they are more likely to recommend that you have surgery; if you go to a radiation oncologist, they are more likely to recommend that you have radiation,” she said. “They each often believe that the treatment that they’re trained in is the better one.”Related StoriesCancer killing capability of lesser-known immune cells identifiedStudy reveals link between inflammatory diet and colorectal cancer riskHow cell-free DNA can be targeted to prevent spread of tumorsIn the case of screening for colorectal cancer, the American College of Gastroenterology’s panel – all of whom were gastroenterologists – recommended colonoscopy as the best strategy.But the United States Preventive Task Force, with no gastroenterologists or gastrointestinal surgeons, recommended testing the stool, sigmoidoscopy (an exam of only the lower part of the colon) or colonoscopy as a last resort. Stool testing was also recommended by the European Society of Medical Oncology panel, which consisted of six medical oncologists, no gastroenterologists and one gastrointestinal surgeon. The panel said there was limited evidence that screening colonoscopy is effective.”Colonoscopies are more invasive than stool testing and come with potentially greater risks and costs for patients – but increased clinical volume and profits for gastroenterologists,” Sah said.Specialty guidelines are also subject to fee-for-service bias, according to the commentary. Doctors who receive a payment for each treatment may tend to recommend that treatment more often, because they have a financial interest in it.”The bias is not necessarily malicious or intentional,” Sah said. “In a fee-for-service environment, they may be biased to do more rather than less, so it becomes a habit.”But more is not necessarily better, she said. “Sometimes the risks of those procedures are just not worth the benefits.”The authors call for a reduction in conflicts of interest in the fee-for-service model, and more professional diversity in the makeup of the guideline committees. “You need a variety of different voices on those committees,” Sah said.And patients could ask their doctors which guidelines they follow and why. “Ask them questions,” she said. “Ask your doctor to explain their thought process in recommending the particular guideline and the advantages or disadvantages of one guideline versus another.”Cornell University has dedicated television and audio studios available for media interviews supporting full HD, ISDN and web-based platforms. Source:http://news.cornell.edu/stories/2019/03/sah-medical-guidelines-may-be-biased-overly-aggressive
Our new optional upgrade allows the Mirage to quickly and successfully decode the latest split-code Brooks AcoustixTM tubes, without the need to cover the racks, in less than 5 seconds and with full empty-well detection”. Jun 12 2019Ziath Ltd. has announced its compact DataPaq™ Mirage CMOS-camera based 2D tube rack scanner can now read Brooks Acoustix™ tubes in addition to all popular makes of coded tubes in ANSI/SLAS format racks. Steve Knight, Commercial Director at Ziath commented: Related StoriesNew Ziath solution enables verifiable 2D coded tube selection from storage racksZiath to showcase new Mohawk Semi-Automated Tube picker at SLAS 2019Ziath announces opening of direct operations in the U.S.Economically priced to suit most budgets, the DataPaq™ Mirage has been designed as a faster, more productive camera-based replacement for a flatbed scanner. Its low profile and ability to scan all current, commonly used ANSI/SLAS format racks enables it to be simply integrated with liquid handling platforms and other automation systems.The DataPaq™ Mirage 2D scanner offers easy, out-of-the-box set up and is delivered pre-calibrated and ready to scan. Benefiting from unique, patented illumination, scanning and decode technology the DataPaq™ Mirage can, error-free, decode a complete 96 well rack in just 2-3 seconds. Source: Ziath Versatile 2D Rack Scanner
Graphic depiction of the process of using cobalt- and manganese-doped nanoparticles to kill tumors via magnetic hyperthermia. Image Credit: Tetiana Korzun By Dr. Ananya Mandal, MDJun 26 2019Oregon State University researchers have come up with nanoclusters that are capable of reaching within tumours that are difficult to reach. The results of this breakthrough in cancer therapeutics were published in a study in the latest issue of the journal ACS Nano. The study is titled, “Biocompatible Nanoclusters with High Heating Efficiency for Systemically Delivered Magnetic Hyperthermia.” These nanoclusters are magnetic and are of the size of a billionth of a metre, explain the researchers. They can be easily injected into the body into the cancerous growth and can reach the insides of the tumours easily, they add. Once the nanoclusters have been injected into the tumour, they are subjected to an alternate magnetic field (AMF) from outside, write the researchers. This raises the temperature of the clusters to over 100 degrees Fahrenheit and the heat kills the cancer cells from inside.The team of researchers explain that the hurdle they faced until now was to find the right nanoparticles that could be able to be injected both directly into the tumour as well as via the intravenous route. Both ways they should be able to reach the tumour mass. Once they accumulate within the tumours, the AMF could be used to kill the cancer cells from within. For ovarian cancers and prostate cancer, these nanoparticles have been used intravenously, they write. The team of researchers included OSU electrical engineering professor Pallavi Dhagat, who led the efforts in developing the naoclusters.Lead authors Olena Taratula and Oleh Taratula of the OSU College of Pharmacy along with their colleagues developed nanoclusters. These clusters are multiple nanoparticles that have a better heating efficiency. Each of the hexagon-shaped iron oxide nanoparticles are coated with cobalt and manganese and are carried into the body using “biocompatible PEG–PCL (poly(ethylene glycol)-b-poly(ε-caprolactone))-based nanocarriers”, the authors explained.Taratula, associate professor of pharmaceutical sciences in a statement said, “There had been many attempts to develop nanoparticles that could be administered systemically in safe doses and still allow for hot enough temperatures inside the tumor. Our new nanoplatform is a milestone for treating difficult-to-access tumors with magnetic hyperthermia. This is a proof of concept, and the nanoclusters could potentially be optimized for even greater heating efficiency.” She said that this process of magnetic hyperthermia could now be used for cancer treatment. She said, “It’s already been shown that magnetic hyperthermia at moderate temperatures increases the susceptibility of cancer cells to chemotherapy, radiation and immunotherapy.”Related StoriesTiny magnetic microrobots could help drug-delivery nanoparticles reach their targetsEvaluating safety and efficacy of magnetically labeled mesenchymal stem cellsAn injection of nanoparticles for spinal cord injuriesFor the study the team used mouse models in the labs to show that after the animals had been given IV nanocluster injections, they could be treated with magnetic hyperthermia. In the test animals, ovarian cancer was implanted under the skin for the experiment. Taratula explained, “To advance this technology, future studies need to use orthotopic animal models – models where deep-seated tumors are studied in the location they would actually occur in the body. In addition, to minimize the heating of healthy tissue, current AMF systems need to be optimized, or new ones developed.”The authors of the study wrote in conclusion, “this nanoplatform is a milestone in the development of systemically delivered magnetic hyperthermia for the treatment of cancer tumors that are difficult to access for intratumoral injection.”The study was supported by the National Institutes of Health, the OSU College of Pharmacy and Najran University of Saudi Arabia.Related researchAuthors Angl Apostolova from the University of Architecture, Civil Engineering and Geodesy in Sofia, Bulgaria and colleagues this year (April 2019) published their work on magnetic hyperthermia using nanoclusters. Their study was published in the The European Physical Journal B. The study was titled, “Specific absorption rate in Zn-doted ferrites for self-controlled magnetic hyperthermia.”This study showed that the absorption rate of the heat produced by the nanoclusters depends on the composition of the magnetic material as well as its diameter. The team explained that AMF would be used to activate their magnetic particles. Further they assure that these nanoparticles would be absorbed only by the tumour tissues and not by the healthy tissues. To ensure this the team used iron oxide nanoparticles called ferrite, to which they added small amounts of copper, nickel, manganese or cobalt atoms. This is called dopping.They tested the efficacy of the nanoparticles then on mice as well as cell cultures and found that diameter of the particles as well as its composition affected the efficiency of the particles to generate magnetic hyperthermia. They explain that For cobalt dopping the maximum absorption is seen with maximum of 14 nanometres size and for copper dopping maximum absorption is seen with maximum of 16 nanometres size. Journal references: Biocompatible Nanoclusters with High Heating Efficiency for Systemically Delivered Magnetic Hyperthermia, Hassan A. Albarqi, Leon H. Wong, Canan Schumann, Fahad Y. Sabei, Tetiana Korzun, Xiaoning Li, Mikkel N. Hansen, Pallavi Dhagat, Abraham S. Moses, Olena Taratula, and Oleh Taratula, ACS Nano 2019 13 (6), 6383-6395, DOI: 10.1021/acsnano.8b06542 – https://pubs.acs.org/doi/10.1021/acsnano.8b06542 Specific absorption rate in Zn-doted ferrites for self-controlled magnetic hyperthermia, Apostolov, A., Apostolova, I. & Wesselinowa, J. Eur. Phys. J. B (2019) 92: 58. https://doi.org/10.1140/epjb/e2019-90567-2
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