Osheaga Music and Arts Festival has revealed the lineup for their 2019 event, set to take place on August 2nd, 3rd, and 4th at Montréal, Québec’s Parc Jean-Drapeau.The Friday, August 2nd lineup will feature performances by The Lumineers, Flume, J Balvin, Inerpol, Gucci Mane, Kurt Vile & The Violators, $uicideboy$, Jessie Reyez, Rosalía, Gunna, Miski, Denzel Curry, Kodaline, Dean Lewis, Joji, Bob Moses, St. Paul & The Broken Bones, Sharon Van Etten, and more.On Saturday, August 3rd, Osheaga will see appearances by The Chemical Brothers, Logic, City and Color, Janelle Monae, Rüfüs Du Sol, Beach House, Young The Giant, Louis The Child, King Princess, A Boogie Wit Da Hoodie, Lennon Stella, FKJ, Black Tiger Sex Machine, Sofi Tukker, GRiZ, and more.Finally, on Sunday, August 4th, Childish Gambino, Tame Impala, Hozier, Kaytranada, Metric, Mac DeMarco, Normani, Ski Mask the Slump God, The Black Madonna, DJ Koze, The Glorious Sons, Sebastian, Hayley Kiyoko, Sigrid, Alec Benjamin, Tierra Whack, Taylor Bennett, and more will hit the stage at Osheaga.The lineup announcement also notes that more artists will be added to the bill as the festival draws closer. Tickets for Osheaga 2019 are now available on the festival’s website.
Up to 2,100 Air Force reservists who may have been exposed to harmful levels of Agent Orange on contaminated cargo planes are now eligible for disability benefits from the Veterans Administration (VA). The VA announced its decision on June 18, 2015 after a VA-ordered report from the Institute of Medicine (IOM), issued in January, concluded that the reservists were likely exposed to unsafe levels of dioxin, the toxic chemical in Agent Orange.“The VA has been dragging its feet on this for about five years,” said Robert Herrick, senior lecturer on industrial hygiene at Harvard T.H. Chan School of Public Health, who chaired the IOM committee that issued the report. “It was a painful process, but in the end we were gratified with the results.”During the Vietnam War, C-123 cargo planes were used to spray Agent Orange, a defoliant. Between 1972 and 1982, those planes were also used for stateside cargo and training missions. Until now, the VA has accepted Agent Orange-related disability claims only from those who served in Vietnam. The VA also previously claimed that the cargo planes had been decontaminated and that therefore the reservists couldn’t have been exposed.But those who became sick after flying and working on the planes, as well as several senators and congressmen, had pushed in recent years to have the VA extend disability benefits. Read Full Story
Researchers use of 3-D maps to create catalog of 10,000 folding loops, depicting genetic regulation A marriage of origami and robotics Nanotechnologists are using DNA, the genetic material present in living organisms, as well as its multifunctional cousin RNA as the raw material in efforts to build minuscule devices that could potentially function as drug-delivery vehicles, tiny nanofactories that produce pharmaceuticals and chemicals, or highly sensitive elements of electric and optical technologies.Like genetic DNA (and RNA) in nature, these engineered nanotechnological devices are also made up of strands comprised of the four bases known in shorthand as A, C, T, and G. Regions within those strands can spontaneously fold and bind to each other via short, complementary base sequences in which As from one sequence bind to Ts from another, and Cs to Gs.Researchers at the Wyss Institute of Biologically Inspired Engineering at Harvard University and elsewhere have used these features to design self-assembling nanostructures such as scaffolded DNA origami and DNA bricks of ever-growing sizes and complexities that are becoming useful for diverse applications. However, the translation of these structures into medical and industrial applications is still challenging, partially because these multistranded systems are prone to local defects due to missing strands. In addition, they self-assemble from hundreds to thousands of individual DNA sequences that each must be verified and tested for high-precision applications, and whose expensive synthesis often produces undesired side products.Now, a novel approach published in Science by a collaborative team of researchers from the Wyss Institute, Arizona State University, and Autodesk for the first time enables the design of complex, single-stranded DNA and RNA origami that can autonomously fold into diverse, stable, user-defined structures. In contrast to the synthesis of multistranded nanostructures, these entirely new types of origami are folded from a single strand, which can be replicated in living cells. This could allow for low-cost production at large scales and with high purities, opening entirely new opportunities for diverse applications such as drug delivery and nanofabrication. Earlier generations of larger-sized origami were composed of a central scaffold strand whose folding and stability required more than 200 short staple strands that bridged distant parts of the scaffold and fixed them in space. “In contrast to traditional scaffolded origamis, which are assembled from hundreds of components, our new approach allows us to reliably design and synthesize stable single-stranded and self-folding origami,” said Wyss Institute core faculty member and corresponding author Peng Yin. “Our fundamentally new approach relies on single-strand folding, rather than multicomponent assembly, to produce large nanostructures. This, together with the ability to basically clone and multiply the single component strand in bacteria, presents a game-changing advance in DNA nanotechnology that greatly enhances single-stranded origami’s potential for real-world applications.” Yin is also co-lead of the Wyss Institute’s Molecular Robotics Initiative and professor of systems biology at Harvard Medical School (HMS).To enable the production of single-stranded and stable DNA-based origami with distinct folding patterns, the team first had to overcome several challenges. In a large DNA strand that goes through a complex folding process, many sequences need to accurately pair up with far-away sequences. If this process does not happen in an orderly and precise fashion, the strand gets tangled and forms unspecific knots along the way, rendering it useless.“To avoid this problem, we identified new design rules that we can use to cross DNA strands between different double-stranded regions, and developed a web-based automated design tool that allows researchers to integrate many of these events into a folding path leading up to a large, knot-free nanocomplex,” said Dongran Han, the study’s first author and a postdoctoral fellow on Yin’s team.The largest DNA origami structures created previously were assembled by synthesizing all their constituent sequences individually in vitro and mixing them together. As a key feature of the new design process, the single-strandedness of the DNA origami allowed the researchers to introduce DNA sequences stably into E. coli bacteria to inexpensively and accurately replicate them with every cell division. “This could greatly facilitate the development of single-stranded origami for high-precision nanotech like drug delivery vehicles, for example, as only a single, easy-to-produce molecule needs to be validated and approved,” said Han.Finally, the team also adapted single-stranded origami technology to RNA, which, as a different nucleic acid material, offers certain advantages, such as even higher production levels in bacteria, and usefulness for potential intracellular and therapeutic RNA applications. Translating the approach to RNA scales up the size and complexity of synthetic RNA structures 10-fold compared to previous structures made from RNA.The proof-of-concept analysis also proved that protruding DNA loops can be precisely positioned and be used as handles to attach functional proteins. In future developments, single-stranded origami thus could be functionalized by attaching enzymes, fluorescent probes, metal particles, or drugs either to their surfaces or within cavities inside. This could effectively convert single-stranded origami into nanofactories, light-sensing and -emitting optical devices, or drug-delivery vehicles.Read the full press release.The study was funded by the Office of Naval Research, the Army Research Office, the National Science Foundation’s Expeditions in Computing program, and the Wyss Institute for Biologically Inspired Engineering. Related Creating ‘genomic origami’ Research team creates sheets that can shift shapes on their own Designer outlines for students his principles of world-record flight Not your average paper airplane
E-cigarette products made by Juul Labs were contaminated with a microbial toxin that can cause long-term lung damage, according to an analysis conducted by researchers from Harvard T.H. Chan School of Public Health.The study, published online Dec. 9, 2019 in the American Journal of Respiratory and Critical Care Medicine, was co-authored by David Christiani, Elkan Blout Professor of Environmental Genetics, and Mi-Sun Lee, research associate in the Department of Environmental Health.Last April, Christiani and Lee, along with Harvard Chan School’s Joseph Allen, assistant professor of exposure assessment science, published a study that found bacterial and fungal toxins in many popular e-cigarette products sold in the U.S. in 2013, before Juul’s 2015 founding. Because the company, which now dominates the U.S. e-cigarette market, was not included in the 2018 study, the researchers decided to analyze some of its products for the current study.They analyzed 54 Juul pods — the cartridges used with e-cigarettes that contain a liquid mixture of nicotine, flavorings, and other chemicals — for two types of microbial toxins: endotoxin, a microbial agent found on Gram-negative bacteria, and glucan, a component of fungal cell walls.Endotoxin levels in the Juul products were below the limit of detection, the study found. But 46 percent of the samples contained detectable levels of glucan, and two flavors in particular — tobacco and menthol — were much more contaminated with glucan than other flavors such as mango, crème, fruit, and cucumber. (Juul recently stopped selling e-cigarette pods in the latter four “kid-friendly” flavors, as well as mint, amid criticism that they were contributing to the youth vaping crisis.)Chronic exposure to glucan can cause inflammation in the airway and lead to long-term lung damage, Christiani said.He noted that the glucan found in Juul pods is not related to the current vaping-related illness in the U.S. Health officials believe that illness, known as “EVALI” (for “e-cigarette or vaping product use-associated lung injury”), is related mainly to black-market marijuana vaping liquids laced with Vitamin E acetate.Christiani said he’s not sure why Juul’s tobacco- and menthol-flavored pods have such high levels of glucan. He said the problem could be in the raw materials used in the products or could be occurring during the production process. Read Full Story
Senior Tom White finds order in disorder.He finds it in the disorder of his Dillon Hall bedroom, where piles of socks and shoes rest by the bed, hats cluster around a plastic moose head and three broken hockey sticks adorn the wall.He also finds it in the disorder of his Tourette syndrome, a neurological condition that causes him to move, shriek, jump or curse involuntarily.Grant Tobin “For years I’ve been saying, ‘Oh, I can write a book about this. I have all these funny stories.’ And I do — whether it be screaming out obscenities, screaming out things in airports,” White said. “I have all these stories and all these collections and unique experiences that radically kind of define who I am and have kind of built up the character that I have.”The desire to share those experiences compelled White to speak at TEDxUND, a local, self-organized program related to the TED conferences, Jan. 21 in the DeBartolo Performing Arts Center.“I’ve always been kind of fascinated by TED Talks, and I think I’m good at public speaking. It’s one of my gifts,” he said. “And the reason why I don’t get nervous is because eyes are always on me, if you think about it. … Literally, all the world’s a stage.”In his 12-minute talk, White shared a typical day for him and argued that together, people can confront their collective vulnerability.“The thesis of it was, yeah, whatever I have is strange and quixotic and eccentric, but simply because of that, it in no way demeans or diminishes what other people have,” White said. “Because everyone’s got their problems; everyone has their crosses to bear.”‘A knee-jerk reaction’Several years ago, White’s Tourette syndrome demonstrated itself in a particularly problematic manner.“I’ve been tackled in an airport by air marshals,” White said. “I screamed out, ‘I have a bomb!’ As you can imagine, that didn’t go over that well. And I got tackled and detained for a little bit.”In that situation and in others, White’s Tourette syndrome manifests itself in ways that are hypersensitive to specific environments, he said.“My brain will be devious, so think about the worst possible thing you can say, slash, do, in a situation,” White said. “[For example,] you’re alone on the sidewalk with a woman — ‘I’ll kill you, I’ll rape you,’ or something like that. It tries to find the worst possible thing and match that up with the impulse to scream it.”Yelling out potentially offensive statements in public is scary for White and for the recipients of the outbursts because White never knows how people will react, he said. He said he worries that some people might have concealed weapons or respond in other dangerous ways.“It’s fascinating to me because I think my brain works in overload to not only think about that circumstance, but also to act as a regular person, if you will,” he said.Some people with Tourette’s have associated problems, such as Attention deficit hyperactivity disorder or anxiety, according to the website of the Tourette Syndrome Association (TSA). White said he has Obsessive-compulsive disorder (OCD), which couples with his Tourette syndrome to make him act as “a knee-jerk reaction.”“I have the ability to totally shut it down if I put all my energy into it, but were I to do that for … however many hours I’m awake, I’d be absolutely exhausted, simply because it’s literally like waging a war,” he said. “Imagine trying to stop yourself from blinking, trying to stop yourself from breathing, trying to stop yourself from yawning, trying to stop yourself from doing an integral process that’s gnawing away at you. It’s nearly impossible, so it’s a war that I am constantly waging with these functions.”‘Getting by’When he is not restraining the impulses that Tourette’s causes, White notices when people around him react to his tics.“At Notre Dame, it’s lucky because everyone’s kind, everyone’s gracious, everyone’s humble and they act with a great deal of kindness and grace,” he said. “And that’s not every community that I’ve encountered.”White said he uses humor to smooth over awkward circumstances. He said the quick connections that he makes because of his Tourette syndrome and OCD enable him to be witty and bitingly sarcastic.“I often defuse the situation with humor, mockery, self-deprecation, you name it,” White said. “And that tends to work, simply because people respond to that. … If you can show that, sure, you’ve got this condition or whatever, but you’re funny, even the most introverted, terrified people will elicit a laugh, which is telling, and it’s the easiest way to defuse the situation.“I guess, initially, [meeting new people is] tense, but once you get to know me and you kind of break down that façade and take the tics and everything in stride, then it’s humorous, then it’s interesting. It’s an insight into my mind … [and] the way I operate.”White’s Tourette syndrome exhibits itself more at some times than at others, he said. Although he said stress and sleep deprivation increase the symptoms, he said he never can be sure when they will worsen or improve.“There are activities that certainly defuse it — engaging conversation, in class if I’m fully invested,” White said. “I’ve played hockey since I was three years old, so 19 years now, and it never, ever manifested itself then. … I used to play piano — it never happened then — reading, writing, any sport any physical activity, watching a movie or TV show.”In order to lessen the symptoms of his Tourette’s, White is constantly in motion. He pursues a double major in the Program of Liberal Studies and Italian, is a Hesburgh-Yusko Scholar and plays on the club hockey team. In his free time, White said, he manages a stock portfolio with his 18-year-old brother.“I’m better when I’m active,” White said. “I’m taking 19 credits this semester. I’m trying to suck the life out of my college experience.”‘Extending a hand’Although scientists think Tourette’s is caused by problems in one or more parts of the brain, they are unsure of its exact causes, according to the TSA. The organization’s website stated that there currently is no cure for Tourette’s, but there are treatments to reduce the severity of tics and symptoms of related conditions.Still, White said treatments are “like guessing games” and medical pharmaceutical companies stray away from Tourette’s research because it is unprofitable. As a result, he said, some people with the disorder struggle to function in society. He said he intended for his TEDx talk to benefit these individuals.“I think it was necessary that I do it — not to sound pompous,” he said. ”I get emails, I get Facebook messages from people who are showing gratitude and sincerely ask for my help, and it’s kind of emotionally draining. … I think I have it bad, but I mean, suck it up — I don’t have anything compared to these people.“So, the response has been overwhelming, and I think the outcome has been the increased need for a talk or conversation about neurological illness and the decrease in stigmatization of it. … Our society is readily able to accept amputees and other such things, people in wheelchairs and such, to our credit, but where we fall short is when we can’t accept those with non-physical injuries. I think it’s a necessary wake-up call.”White said his family and friends get him out of bed every day, despite the difficulties of his syndrome.“I wouldn’t wish this upon anyone at all, let alone those people without a solid base of love and support or even faith in God,” he said. “Going through this alone, I don’t think it’s possible. So, if anything, the TED Talk is just extending a hand — like, ‘Listen, you’re not going through this alone. Yeah, it might suck at times, it might be miserable, but listen, you’ve got life.’”The compassion and selflessness of his brother particularly help White to survive the ups and downs of his Tourette syndrome, he said.“[My brother] will go to the ends of the earth with me, and I know he’ll be my best friend for the rest of my life,” White said. “So, I mean, it’s awesome; I’m blessed. As much as it might seem to be miserable, I realize the immense amount of blessings in my life, and as a result of that, I’m able to thrive, to prosper.”Tags: TED talks, TEDxUND, tom white, Tourette syndrome
Sign up for our COVID-19 newsletter to stay up-to-date on the latest coronavirus news throughout New York A 34-year-old dead man was found floating in the Peconic River in Riverhead on Tuesday evening, Riverhead Town Police said.Officers responding to a 911 report of a person in the water found the man face down in the river near a footbridge on the north side of Grangebel Park at 5:11 p.m., police said.“It was immediately apparent the subject was deceased and had been in the water for an undetermined amount of time,” police said in a news release.The Riverhead police dive team removed the body from the water. The man was later identified as Victoriano Cohon-Garcia.His body was taken to the Suffolk County Medical Examiner’s office, where an autopsy will be conducted to determine his cause of deathInvestigators do not believe the death to be criminal in nature.Riverhead police detective are continuing the investigation and ask anyone with information on this case to call them at 631-727-4500.
continue reading » The CFPB released additional data from its Making Ends Meet Survey – conducted in May 2019 – related to consumers’ saving habits. The new data from the survey indicates that many consumers are falling short of the amount they think they will need in emergency savings.As reported, half of Americans believe they need $10,000 or more in savings for an emergency, with more than half reporting that their household has $3,000 or less in their savings and checking accounts combined.The CFPB earlier this year issued its final rule related to payday lending, which did not include a NAFCU-sought expansion of the safe harbor for credit unions’ payday alternative loans (PALs).NAFCU continues to tout the benefits of credit unions’ PALs loans to help consumers in need of safe, affordable short-term, small-dollar loans and has urged the bureau to expand its payday lending safe harbor. ShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr
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A Baptist church has become the latest Christian construction project to be halted in Semarang, Central Java, following protests from non-Christian residents in a sign of growing religious intolerance among the majority Muslim population.Local protests over the construction of churches have become common in many predominantly Muslim areas in Indonesia, with local authorities tending to side with protestors In some, if not most, cases. In a statement made available to The Jakarta Post on Thursday, the Semarang Legal Aid Institute (LBH), which legally represents Tlogosari Baptist Church, said that officials from the Public Order Agency (Satpol PP) had come and put a halt to ongoing construction on the church. LBH Semarang said that the action had no any legal basis and showed that officials were bowing to pressure from “intolerant groups”.”What the agency is doing is a form of abuse of power and violates the law,” it said in the statement, stressing that the church construction project had already secured the necessary building permit (IMB).Read also: Permit for Riau Islands church revoked over local fears ‘it may turn into an icon’A group of Semarang residents held a protest at City Hall on March 6 to demand that the church’s construction be stopped. The protest group claimed that the project had obtained the IMB through “deceit” by getting them to sign a blank paper.Wahyudi, the head of Tlogosari Baptist Church, was quick to dismiss the accusation, saying that the church organization had openly asked for the residents’ permission to proceed with the project in 1998, when it first applied for the permit.A 2006 joint ministerial decree requires that all development projects for places of worship, no matter the religion, must obtain 90 signatures from followers of the religion, as well as 60 signatures from followers of other religions who live near the planned site of the development, before the project may be proposed.Topics :
Arsul Sani, a member of the House Commission III overseeing legal affairs, said the Indonesian paradigm of combating terrorism was based on law enforcement practices through the criminal justice system. Therefore, the existence of Article 43 was debatable when the President issued the Perpres.”The House hopes that the Perpres only accommodates ongoing [law enforcement] efforts. We are aware that the TNI and the police have been cooperating well, for example, in the Tinombala operation,” he said.Read also: Indonesian Military expected to play greater role in counterterrorismHe added that he was not opposed to the TNI’s involvement in combating terrorism, but the Perpres did not have a clear framework, which would contradicts Indonesia’s political paradigm for its fight against terrorism. President Joko “Jokowi” Widodo has proposed involving military forces to strengthen Indonesia’s fight against terrorism through a presidential regulation (Perpres) that was submitted to the House of Representatives on Monday.The Perpres is a follow up to Article 43 of Law No. 5/2018 on terrorism, stipulating the Indonesian Military (TNI) may be deployed in “combating acts of terrorism,” which should be regulated through a Perpres.The move has been widely criticized, with activists warning that the TNI’s involvement would contradict the 2004 TNI Law and could pose a danger to law enforcement and human rights in Indonesia. “The TNI’s involvement should be based on the scale of the threats, not by events like in the Perpres. We see that in modern democratic countries in Europe, there have been some cases of the military backing the police and vice versa, depending on the scale [of the threat],” said Asrul.Article 9 of the regulation, a copy of which was obtained by The Jakarta Post, stipulates that the TNI’s functions in terrorism enforcement include attacks against the President and Vice President and their families, former presidents and vice presidents and their families, high-ranked state guests in the country, Indonesians abroad and representatives from other countries or international organizations in Indonesia.The National Commission on Human Rights (Komnas HAM) and civil groups that focus on the issue of human rights said the Perpres had given a broad and excessive mandate to the TNI, adding that the military would not be subject to general justice.Choirul Anam of Komnas HAM said such a mandate could endanger law enforcement practices in combating terrorism, which may result in human rights violations.Read also: Jokowi inaugurates new antiterror agency chief despite criticism”The involvement of the TNI in combating terrorism should only be in military operations other than war and should only assist the police, can’t be permanent and must depend on the situation.”Al Araf of rights watchdog Imparsial said the Perpres should regulate a clear authority of the TNI as it is prone to be abused. He cited Article 3 of the regulation that allowing the TNI to carry out counterterrorism functions through intelligence activities and/or territorial operations, information operations and other operations.However, the regulation does not provide a more detailed explanation related to the “other operations”.”With this provision, the TNI can be involved in handling criminal acts of terrorism both in the country and abroad. Therefore, it has the potential to endanger human rights in Indonesia,” he said.Topics :